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CONTENTS

SECTION 1 INTRODUCTION TO INFECTIOUS DISEASES 1

Chapter 1 Introduction to Infectious Diseases: Host¨CPathogen Interactions 1

Chapter 2 Molecular Mechanisms of Microbial Pathogenesis 8

Chapter 3 Immunization Principles and Vaccine Use 22

Chapter 4 Laboratory Diagnosis of Infectious Diseases 35

Chapter 5 Microbial Bioterrorism 47

SECTION 2 BACTERIAL INFECTIONS 60

Chapter 6 Treatment and Prophylaxis of Bacterial Infections 60

Chapter 7 Meningococcal Infections 75

Chapter 8 Salmonellosis 85

Chapter 9 Shigellosis 93

Chapter 10 Infections Due to Campylobacter and Related Organisms 99

Chapter 11 Cholera and Other Vibrioses 103

Chapter 12 Brucellosis 109

Chapter 13 Plague and Other Yersinia Infections 116

Chapter 14 Tuberculosis 126

Chapter 15 Antituberculosis Drugs 147

Chapter 16 Syphilis 157

Chapter 17 Leptospirosis 167

Chapter 18 Relapsing Fever 174

Chapter 19 Lyme Borreliosis 179

Chapter 20 Rickettsial Diseases 185

Chapter 21 Infections Due to Mycoplasmas 196

Chapter 22 Chlamydial Infections 200

Chapter 23 Meningitis, Encephalitis, Brain Abscess, and Empyema 212

Chapter 24 Severe Sepsis and Septic Shock 244

SECTION 3 VIRAL INFECTIONS 257

Chapter 25 Medical Virology 257

Chapter 26 Antiviral Chemotherapy, Excluding Antiretroviral Drugs 267

Chapter 27 Herpes Simplex Virus Infections 276

Chapter 28 Varicella-Zoster Virus Infections 289

Chapter 29 Epstein-Barr Virus Infections, Including Infectious Mononucleosis 294

Chapter 30 Cytomegalovirus 299

Chapter 31 Common Viral Respiratory Infections 304

Chapter 32 Influenza 314

Chapter 33 Human Immunodeficiency Virus Disease: Aids and Related Disorders 323

Chapter 34 Viral Gastroenteritis 412

Chapter 35 Acute Viral Hepatitis 419

Chapter 36 Chronic Viral Hepatitis 444

Chapter 37 Enteroviruses and Reoviruses 456

Chapter 38 Measles (Rubeola) 464

Chapter 39 Rubella (German Measles) 470

Chapter 40 Mumps 473

Chapter 41 Rabies and Other Rhabdovirus Infections 476

Chapter 42 Infections Caused by Arthropod- and Rodent-Borne Viruses 481

Chapter 43 Ebola and Marburg Viruses 503

SECTION 4 PRION DISEASES 507

Chapter 44 Prion Diseases 507

SECTION 5 FUNGAL INFECTIONS 516

Chapter 45 Diagnosis and Treatment of Fungal Infections 516

Chapter 46 Cryptococcosis 520

Chapter 47 Candidiasis 525

Chapter 48 Aspergillosis 532

Chapter 49 Pneumocystis Infections 537

SECTION 6 PROTOZOAL AND HELMINTHIC INFECTIONS 541

Chapter 50 Laboratory Diagnosis of Parasitic Infections 541

Chapter 51 Agents Used to Treat Parasitic Infections 551

Chapter 52 Amebiasis and Infection with Free-Living Amebas 559

Chapter 53 Malaria 565

Chapter 54 Leishmaniasis 580

Chapter 55 Toxoplasmosis Infections 589

Chapter 56 Intestinal Nematode Infections 595

Chapter 57 Filarial and Related Infections 602

Chapter 58 Schistosomiasis and Other Trematode Infections 611

Chapter 59 Cestode Infections 618

Chinese-English Vocabulary 624