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Preface
Acknowledgements
Notes on using The Maudsley Prescribing Guidelines
List of abbreviations
Chapter 1 Plasma level monitoring of psychotropic drugs
Interpreting sample results
Acting on clozapine plasma concentration results
Interpreting post-mortem blood concentrations
Chapter 2 Schizophrenia
ANTIPSYCHOTIC DRUGS
General introduction
General principles of prescribing
Minimum effective doses
Quick reference for licensed maximum doses
Equivalent doses
High£¿dose antipsychotics: prescribing and monitoring
Antipsychotic prophylaxis
Combined antipsychotics
Negative symptoms
Monitoring
Relative adverse effects £¿ a rough guide
Treatment algorithms for schizophrenia
First£¿generation antipsychotics£¿place in therapy
Omega£¿3 fatty acid (fish oils) in schizophrenia
New and developing drugs to treat schizophrenia
NICE guidelines for the treatment of schizophrenia
Antipsychotic response £¿ to increase the dose, to switch,to add or just wait £¿ what is the right move?
Antipsychotic long£¿acting injections
Depot antipsychotics £¿ pharmacokinetics
Management of patients on long£¿term depots
Aripiprazole LAI
Olanzapine LAI
Paliperidone palmitate LAI
Risperidone LAI
ANTIPSYCHOT ICS £¿ ADVERS E EFFECTS
Extrapyramidal side£¿effects
Akathisia
Weight gain
Treatment of drug£¿induced weight gain
Tardive dyskinesia
Neuroleptic malignant syndrome
Catatonia
QT prolongation
Dyslipidaemia
Diabetes and impaired glucose tolerance
Hypertension
Hyponatraemia
Hyperprolactinaemia
Sexual dysfunction
Pneumonia
Switching antipsychotics
REFRACTORY SCHIZOPHRENIA AND CLOZAPINE
Clozapine £¿ dosing regimen
Optimising clozapine treatment
Alternatives to clozapine
Re£¿starting clozapine after a break in treatment
Initiation of clozapine for community£¿based patients
CLOZAPINE £¿ ADVERS E EFFECTS
Common adverse effects
Clozapine: uncommon or unusual adverse effects
Clozapine: serious haematological and cardiovascular adverse effects
Clozapine£¿indu