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CHAPTER 1 INTRODUCTION TO THE PHARMACEUTIC ALANALYSIS
1£®1 Nature and Tasks of Pharmaceutical Analysis
1£®1£®1 Pharmaceutical Analysis in the New Drug Discovery
1£®1£®2 Pharmaceutical Analysis to Ensure the Quality of Drug Product
1£®1£®3 Pharmaceutical Analysis in the Stability Studies
1£®1£®4 In Vivo Drug Analysis
1£®2 National Standards for Supervision of Drug Quality
1£®3 Significance of Separation Technology in the Pharmaceutical Analysis

CHAPTER 2 CHROMATOGRAPHIC ANALYSIS
2£®1 Theoretical Principle and Parameters
2£®1£®1 Theoretical Principles
2£®1£®2 Separation Parameters
2£®1£®3 Theoretical Plates of a Chromatographic Column
2£®2 Gas Chromatography
2£®2£®1 Separation Mechanism
2£®2£®2 GC Instrument
2£®2£®3 GC Columns
2£®2£®4 Stationary Phases in GC
2£®2£®5 Stationary Phases in the GSC
2£®2£®6 Stationary Phases in the GLC
2£®2£®7 Detectors in GC
2£®2£®8 Advantages of GC
2£®2£®9 Applications of GC
2£®3 Introduction to Liquid Chromatography
2£®3£®1 Columns in HPLC
2£®3£®2 General Morphology of HPLC Stationary Phase Particles
2£®4 Normal Phase Liquid Chromatography
2£®4£®1 Characteristics of Normal Phase Liquid Chromatography
2£®4£®2 Elution Ability of Mobile Phase
2£®4£®3 Applications
2£®5 Reversed-phase Liquid Chromatography
2£®5£®1 Stationary Materials for Reversed-phase Liquid Chromatography
2£®5£®2 Retention Characteristic of Reversed-phase Chromatography
2£®5£®3 Secondary Chemical Equilibria in the Reversed-phase Chromatography
2£®5£®4 Applications of Reversed-phase HPLC
2£®5£®5 Ion-pair Reversed-phase Chromatography
2£®6 Ion-exchange Chromatography
2£®6£®1 Separation Principle of IEC
2£®6£®2 Stationary Phase Materials of IEC
2£®6£®3 Retention of Analyses in IEC
2£®6£®4 Major Factors in the IEC Separation
2£®6£®5 Detection in IEC
2£®6£®6 Advantages of IEC
2£®6£®7 Application
2£®7 Size-exclusion Chromatography
2£®7£®1 Separation Mechanism
2£®7£®2 Packing Materials for SEC
2£®7£®3 Applications of SEC
2£®8 Affinity Chromatography
2£®8£®1 Nature of Affinity Interaction
2£®8£®2 Separation Principle of Affinity Chromatography
2£®8£®3 Ligand Selection
2£®8£®4 Selection of Supporting Materials
2£®8£®5 Preparation of Packing Materials for Affinity Chromatography
2£®8£®6 Separation by Affinity Chromatography
2£®8£®7 Application of Affinity Separation Technology
2£®9 Thin-layer Chromatography
2£®9£®1 Stationary Phases Used in TLC
2£®9£®2 Operation in TLC
2£®9£®3 Performance Characteristics of TLC
2£®9£®4 Detection in TLC
2£®9£®5 Quantitative Analysis
2£®9£®6 Applications of TLC Analysis
2£®10 Detectors in Liquid Chromatography
2£®10£®1 Bulk Property Detectors
2£®10£®2 Solute Property Detectors
References
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CHAPTER 3 HIGH PERFORMANCE CAPILLARY ELECTROPHORESIS AND ITSAPPLICATIONIN PHARMACEUTICAL ANALYSIS
CHAPTER 4 APPLICATION OF SEPARATION TECHNOLOGYIN BIOCHEMICAL DRUG ANALYSIS AND DISEASE DIAGNOSIS
CHAPTER 5 NON-TARGETED SCREENING IN THE ANALYSIS OF COMPLEX SAMPLES WITH UNKNOWN COMPONENTS
CHAPTER 6 NEW MATERIAL DEVELOPMENT FOR PHARMACEUTICALSEPARATIONS

QUESTIONS AND PROBLEMS

INDEX