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Chapter 1 INTRODUCTION
1£®1 Nanoparticles in Drug Delivery
1£®1£®1 Role of nanoparticles in drug delivery
1£®1£®2 Composition of drug delivery nanocarriers
1£®1£®3 FDA-approved therapeutic nanoagents
1£®2 Design Rules for Targeted Drug Delivery Nanoplatform
1£®2£®1 Stimuli-responsive drug release
1£®2£®2 Biocompatibility and biodegradability
1£®2£®3 Stability£¬ size and targeting
1£®3 Photothermal Therapy
1£®3£®1 NIR induced photothermal therapy
1£®3£®2 NIR absorbing materials for photothermal therapy
1£®3£®3 Polymer for the delivery of NIR-absorbing dye
1£®3£®4 Combined photothermal-chemotherapy

Chapter 2 POLYMER-COATED HOLLOW MESOPO-ROUS SILICA NANOPARTICLES FOR TRIPLE-RESPONSIVE DRUG DELIVERY
2£®1 Introduction
2£®2 Materials and Methods
2£®2£®1 Preparation of o-nitrobenzyl linkage
2£®2£®2 Preparation of PDEAEMA coated HMSNs
2£®2£®3 Preparation of DOX-loaded nanoparticles
2£®2£®4 Drug release behavior
2£®2£®5 Cellular uptake study
2£®2£®6 Cytotoxicity study
2£®3 Results and Discussiona
2£®3£®1 Preparation of HMSNs-PDEAEMA
2£®3£®2 Loading and triggered release of DOX
2£®3£®3 Cellular uptake and intracellular release
2£®3£®4 In vitro antimmor study
2£®4 Conclusion

Chapter 3 POLYMERIC PRODRUG GRAFTED HOLLOW MESOPOROUS SILICA NANOPAR-TICLES ENCAPSULATING NIR-ABSOR BING
DYE FOR POTENT COMBINED PHOTOTHERMAL-CHEMOTHERAPY
3£®1 Introduction
3£®2 Materials and Methods
3£®2£®1 Synthesis of HMSNs-RAFT
3£®2£®2 HMSNs-DOX prodrug
3£®2£®3 Preparation of HMSNs-DOX/IP
3£®2£®4 Drug release£¬ dye loading and photothermal effect
3£®2£®5 Cellular uptake study
3£®2£®6 In vitro cytotoxicity study
3£®3 Results and Discussion
3£®3£®1 Synthesis and characterization of HMSNs-DOX
3£®3£®2 Drug release£¬ dye loading and photothermal effects
3£®3£®3 Cellular uptake and intracellular release
3£®3£®4 In vitro antitumor study
3£®4 Conclusion

Chapter 4 ACID-SENSITIVE POLYMERIC DOXORUBICIN PRODRUG MICELLES ENCAPSULATING NEAR-INFRARED DYE FOR TARGETED COMBINED PHOTOTHERMAL-CHEMOTHERAPY
4£®1 Introduction
4£®2 Materials and Methods
4£®2£®1 Synthesis of block copolymer
4£®2£®2 Folic acid modification and deprotection
4£®2£®3 Synthesis of DOX prodrug
4£®2£®4 Formation of IR£®825-1oaded PDOX micelles
4£®2£®5 In vitro drug release
4£®2£®6 Cellular uptake study
4£®2£®7 In vitro cytotoxicity study
4£®2£®8 In vivo antitumor efficacy studies
4£®3 Results and Discussion
4£®3£®1 Synthesis and characterization
4£®3£®2 Self-assembly behavior
4£®3£®3 Drug release and photothermal effects
4£®3£®4 IntraceUular uptake
4£®3£®5 In vitro antitumor study
4£®3£®6 In vivo combinational therapeutic efficacy
4£®4 Conclusion

Chapter 5 CONCLUSION AND OUTLOOK
REFERENCES
LIST OF ACRONYMS
EPILOGUE